- Jim Carrey as Carl Allen
- Zooey Deschanel as Allison
- Bradley Cooper as Peter
- John Michael Higgins as Nick
- Rhys Darby as Norman
- Danny Masterson as Rooney
- Terence Stamp as Terrence Bundley
- Molly Sims as Stephanie
- Sean O'Bryan as Ted
- Sasha Alexander as Lucy
- John Cothran Jr. as Tweed
- Luis Guzman as Jumper